Cycle de Skrjabinofilaria skrjabini, Filaire de Marsupial sud-américain ; Position systématique

THESE DE DOCTORAT DE L ’ UNIVERSITE PARIS SUD - 11 Ecole

Photosystem II (PSII) uses light energy to oxidise water and reduce quinone. The water oxidation site is a Mn4Ca cluster located on the luminal side of the membrane protein complex, while the quinone reduction site is made up of two quinones (QA and QB) and a nonheme Fe located on the stromal side of the membrane protein. In this thesis I worked on both oxidation and reduction functions of the ...

Université Paris - Sud 11 Faculté De Pharmacie

Université Paris - Sud 11 Faculté De Pharmacie

Alzheimer‟s disease (AD) represents the most common form of dementia worldwide, affecting more than 35 million people. Advances in nanotechnology are beginning to exert a significant impact in neurology. These approaches, which are often based on the design and engineering of a plethora of nanoparticulate entities with high specificity for brain capillary endothelial cells, are currently being ...

Modélisation systématique de recommandations de pratique clinique: une étude théorique et pratique sur la prise en charge de l'hypertension artérielle

1 Université Paris 6, UFR de Médecine, Paris, France; AP-HP, Hôpital Tenon, Département de Santé Publique, Paris, France; Université Paris 13, UFR SMBH, LIM&BIO, Bobigny, France; APREC, Paris, France. 2 AP-HP, DSI, STIM, Paris, France; INSERM, UMR S 872, eq. 20, Paris, France. 3 AP-HP, HEGP, Service de Médecine Vasculaire et Hypertension Artérielle, Paris, France. 4 SFTG, Paris, France; Univers...

Ordre : Université De Paris Sud U . F . R . Scientifique D '

In this chapter we rst review results on a famous method to obtain estimators in a semiparametric setup, the pro le likelihood method, which is a two-step maximization method based on the likelihood. Then we discuss a generalization called penalized pro le likelihood method, which is introduced in Murphy & van der Vaart (1999) and in Dalalyan et al. (2006). It allows among other properties to d...